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Upstream Bio, Inc. is projected to rise to $8.66 by 2027, a +15% move from its current price of $7.52. UPB is currently trading below its 50-day average (a bearish sign). Technical indicators currently lean neutral.
A data-driven summary — not financial advice. See the full breakdown below.
Live market data via Yahoo Finance · updated 7/11/2026
| Period | Min | Prediction | Max | Change |
|---|---|---|---|---|
| Jul 12 | $7.29 | $7.52 | $7.76 | -0.01% |
| Jul 13 | $7.20 | $7.52 | $7.85 | -0.01% |
| Jul 14 | $7.13 | $7.52 | $7.93 | -0.02% |
| Jul 15 | $7.07 | $7.52 | $8.00 | -0.02% |
| Jul 16 | $7.02 | $7.52 | $8.05 | -0.03% |
| Jul 17 | $6.97 | $7.52 | $8.11 | -0.04% |
| Jul 18 | $6.93 | $7.52 | $8.16 | -0.04% |
| Period | Min | Prediction | Max | Change |
|---|---|---|---|---|
| Week 1 | $6.93 | $7.52 | $8.16 | -0.04% |
| Week 2 | $6.69 | $7.51 | $8.43 | -0.08% |
| Week 3 | $6.52 | $7.51 | $8.65 | -0.12% |
| Week 4 | $6.38 | $7.51 | $8.84 | -0.17% |
| Week 5 | $6.25 | $7.50 | $9.01 | -0.21% |
| Week 6 | $6.14 | $7.50 | $9.16 | -0.25% |
| Week 7 | $6.04 | $7.50 | $9.31 | -0.29% |
Short-term targets derived from the forecast trend and recent volatility. Highly uncertain — not financial advice.
Upstream Bio, Inc. is a clinical-stage biotechnology company that develops treatments for inflammatory diseases, focusing on severe respiratory disorders. The company offers verekitug, which is in Phase 2 trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease, and in Phase I clinical trial for treating chronic obstructive pulmonary disease.
Upstream Bio was incorporated in 2021 and is headquartered in Waltham, Massachusetts.
UPB trades as a healthcare stock with a current price of $7.51 and a market capitalization of $408.69M. It holds a rank of 3138 in the market. The 30-day price range is $6.09-$9.26, reflecting a modest trading band around the current level.
Technical indicators show sentiment labeled NEUTRAL, with RSI(14) at 60. The 50-day simple moving average sits at $7.91, while the 200-day simple moving average is at $17.06. Key support is $5.92 and resistance is $8.46. Annualized volatility stands around 60%.
Looking ahead, the forecast paints a path of gradual upside, with year-by-year averages progressing from $7.51 in 2026 to higher levels over time, including a long-horizon rise to $39.90 by 2050 (with a max of $78.19 and a min of $20.75 in that year). The 2030-2050 window shows notable upside potential.
A major floor 35.8% below — a decisive break under it would weaken the trend.
The nearest floor, 21.3% below — buyers have tended to step in here.
The nearest ceiling, 11.2% above — a clean break opens room to run.
A major ceiling 39.5% above — clearing it would confirm fresh momentum.
Key UPB support and resistance from recent price action — levels where the trend has historically paused or reversed. Percentages are the distance from the current price.
A snapshot of UPB market posture derived from its technical indicators and recent volatility. Higher trend and alignment lean bullish; higher risk means larger swings.
Technical Analysis
Indicators computed on daily closing prices.
| Period | SMA | Action | EMA | Action |
|---|---|---|---|---|
| MA 5 | $7.72 | Sell | $7.63 | Sell |
| MA 10 | $7.40 | Buy | $7.41 | Buy |
| MA 20 | $6.81 | Buy | $7.24 | Buy |
| MA 50 | $7.74 | Sell | $7.94 | Sell |
| MA 100 | $8.35 | Sell | $10.25 | Sell |
| MA 200 | $16.83 | Sell | $13.15 | Sell |
| Name | Value | Action |
|---|---|---|
| RSI (14) | 54.30 | Neutral |
| Stoch RSI (14) | 68.60 | Neutral |
| CCI (20) | 80.94 | Neutral |
| Williams %R (14) | -26.79 | Info |
| MACD (12,26,9) | 0.21 | Buy |
| ROC (12) | 19.15 | Buy |
| Bollinger %B (20,2) | 0.77 | Neutral |
| Stochastic %K (14) | 73.21 | Neutral |
| TRIX (15) | -0.35 | Sell |
| Awesome (5,34) | 0.57 | Buy |
| Ultimate (7,14,28) | 66.74 | Neutral |
| Momentum (10) | 1.17 | Buy |
| Aroon Osc (25) | 56.00 | Buy |
| Hull MA (9) | 7.96 | Sell |
| ADX (14) | 22.85 | Buy |
| ATR (14) | 0.21 | Info |
The 30-day technical picture is Neutral.
RSI(14) is 60, placing momentum in the middle of the range. The stock is trading near the 50-day moving average of $7.91 and well below the 200-day moving average of $17.06, indicating a mixed longer-term trend even as near-term averages hold.
Support is at $5.92 and resistance at $8.46. The 30-day price range runs from $6.09 to $9.26, outlining a relatively tight near-term band around the current level.
| Year | Min | Avg | Max | ROI | Sentiment |
|---|---|---|---|---|---|
| $5.92 | $7.52 | $9.58 | 0% | Neutral | |
| $6.81 | $8.66 | $11.70 | +15% | Neutral | |
| $6.70 | $8.79 | $12.37 | +17% | Neutral | |
| $6.52 | $8.79 | $12.78 | +17% | Neutral | |
| $7.34 | $10.13 | $15.12 | +35% | Bullish | |
| $8.05 | $11.35 | $17.35 | +51% | Bullish | |
| $9.71 | $13.98 | $21.81 | +86% | Bullish | |
| $10.70 | $15.70 | $24.96 | +109% | Bullish | |
| $10.15 | $15.15 | $24.51 | +101% | Bullish | |
| $11.11 | $16.87 | $27.73 | +124% | Bullish | |
| $15.57 | $25.59 | $44.99 | +240% | Bullish | |
| $22.26 | $42.02 | $81.43 | +459% | Bullish |
Current year — the forecast is anchored to the live price, so ROI shows 0%.
| Month | Min | Avg | Max | Change |
|---|---|---|---|---|
| July 2026 | $5.92 | $7.52 | $8.80 | +0.00% |
| August 2026 | $6.19 | $7.33 | $8.93 | -2.56% |
| September 2026 | $6.26 | $7.48 | $9.23 | +2.07% |
| October 2026 | $6.12 | $7.36 | $9.18 | -1.59% |
| November 2026 | $6.00 | $7.25 | $9.12 | -1.50% |
| December 2026 | $6.21 | $7.55 | $9.58 | +4.19% |
Click any year to see its month-by-month UPB forecast. Min / Avg / Max are a bear / base / bull scenario; ROI is the projected move from the current price. Change is the month-over-month move in the average. Estimates, not guarantees.
Expect UPB to range from $5.92 to $9.58 through 2026. The $7.52 average target implies a 0% move from current prices. Price action looks broadly range-bound.
The UPB price prediction for 2027 points to an average of $8.66 (low $6.81, high $11.70) — a potential gain of +15% on today's $7.52. A consolidation phase looks the most probable path here.
In 2028, UPB is projected to trade between $6.70 and $12.37, averaging $8.79 — a potential gain of +17% from today's $7.52. That is up +1% on the projected 2027 average. Price action looks broadly range-bound.
Upstream Bio, Inc.'s 2029 outlook centres on $8.79, within a $6.52 to $12.78 range. That is up 0% on the projected 2028 average. That marks a +17% change versus current levels. A consolidation phase looks the most probable path here.
By 2030, UPB could reach as high as $15.12, with a base case around $10.13 and support toward $7.34 — roughly +35% from $7.52. Momentum favours further upside here.
Expect UPB to range from $8.05 to $17.35 through 2031. The $11.35 average target implies a +51% move from current prices. That is up +12% on the projected 2030 average. Buyers look set to stay in control over this stretch.
The UPB price prediction for 2032 points to an average of $13.98 (low $9.71, high $21.81) — a potential gain of +86% on today's $7.52. Momentum favours further upside here.
In 2033, UPB is projected to trade between $10.70 and $24.96, averaging $15.70 — a potential gain of +109% from today's $7.52. That is up +12% on the projected 2032 average. Buyers look set to stay in control over this stretch.
Upstream Bio, Inc.'s 2034 outlook centres on $15.15, within a $10.15 to $24.51 range. That is -3% versus the projected 2033 average. That marks a +101% change versus current levels. Momentum favours further upside here.
By 2035, UPB could reach as high as $27.73, with a base case around $16.87 and support toward $11.11 — roughly +124% from $7.52. Buyers look set to stay in control over this stretch.
Expect UPB to range from $15.57 to $44.99 through 2040. The $25.59 average target implies a +240% move from current prices. That is up +52% on the projected 2035 average. Momentum favours further upside here.
The UPB price prediction for 2050 points to an average of $42.02 (low $22.26, high $81.43) — a potential gain of +459% on today's $7.52. Buyers look set to stay in control over this stretch.
Investing $1,000 in UPB today (≈ 132.978723 UPB) could be worth
$5,588.25
+$4,588.25 (+459%) by 2050 · US Dollar
Based on the average projected UPB price of $42.02 in 2050.
Based on the base (average) forecast scenario. FX rates are indicative. Estimates only — not financial advice.
See what a past investment in UPBwould be worth at today's price.
$1,000 invested in UPB on Jul 10, 2025 (≈ 84.459458 UPB) would be worth
$635.14
-$364.86 (-36.5%) today · 0.64× · US Dollar
Based on a UPB entry price of $11.84 vs. today's $7.52.
| Invested | Entry price | Value today | Return |
|---|---|---|---|
| 1 week ago | $7.51 | $1,001.33 | +0.1% |
| 1 month ago | $6.28 | $1,197.45 | +19.7% |
| 3 months ago | $10.49 | $716.87 | -28.3% |
| 6 months ago | $31.66 | $237.52 | -76.2% |
| 1 year ago | $11.84 | $635.14 | -36.5% |
| All time (1.7y) ago | $22 | $341.82 | -65.8% |
Past performance from historical market data — it does not predict future results. FX rates are indicative. Not financial advice.
Enter a price to see how it sits against our UPB forecast.
Our base-case forecast reaches $15.00 around 2033.
Implied market cap at $15.00: $816.3M
The multi-year forecast shows a shift to bullish sentiment beginning in the deeper horizon. In 2026 the average is $7.51, with gradual increases through 2029 around $8.64, signaling a neutral near-term path.
In 2030 the forecast turns more optimistic, with an average of $9.78, a min of $7.04, a max of $14.70, and a ROI of 30.2% as sentiment becomes BULLISH.
The outlook strengthens further into 2040, where the average rises to $24.23 (min $14.56, max $43.02; ROI 222.6; sentiment BULLISH), and continues to 2050 with an average of $39.90 (min $20.75, max $78.19; ROI 431.3; sentiment BULLISH).
These figures are estimates and not guarantees, and they reflect a forecast with higher volatility (annualized volatility around 60%).
Tap a question to reveal the answer.
2030: avg $9.78; min $7.04; max $14.70; ROI 30.2%; sentiment BULLISH.
The long-term forecast shows rising averages and bullish sentiment from 2030 onward, with a 2050 average of $39.90 and a max of $78.19. These are estimates, not guarantees, and actual results may vary.
Yes. The forecast’s 2050 max is $78.19, which exceeds $50, indicating the potential for UPB to trade above $50 in the horizon shown.
The 30-day range is $6.09 to $9.26.
Current price is $7.51 and market cap is $408.69M.
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