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Sionna Therapeutics, Inc. is projected to rise to $59.19 by 2027, a +31% move from its current price of $45.29. SION is currently trading above its 50-day average (a bullish sign). Technical indicators currently lean strong buy.
A data-driven summary — not financial advice. See the full breakdown below.
Live market data via Yahoo Finance · updated 7/13/2026
| Period | Min | Prediction | Max | Change |
|---|---|---|---|---|
| Jul 14 | $43.96 | $45.33 | $46.75 | +0.09% |
| Jul 15 | $43.45 | $45.37 | $47.39 | +0.19% |
| Jul 16 | $43.06 | $45.42 | $47.90 | +0.28% |
| Jul 17 | $42.75 | $45.46 | $48.34 | +0.37% |
| Jul 18 | $42.48 | $45.50 | $48.74 | +0.47% |
| Jul 19 | $42.24 | $45.54 | $49.10 | +0.56% |
| Jul 20 | $42.03 | $45.59 | $49.45 | +0.65% |
| Period | Min | Prediction | Max | Change |
|---|---|---|---|---|
| Week 1 | $42.03 | $45.59 | $49.45 | +0.65% |
| Week 2 | $40.90 | $45.88 | $51.47 | +1.31% |
| Week 3 | $40.12 | $46.18 | $53.17 | +1.97% |
| Week 4 | $39.51 | $46.49 | $54.69 | +2.64% |
| Week 5 | $39.01 | $46.79 | $56.12 | +3.31% |
| Week 6 | $38.59 | $47.10 | $57.47 | +3.99% |
| Week 7 | $38.23 | $47.40 | $58.78 | +4.67% |
Short-term targets derived from the forecast trend and recent volatility. Highly uncertain — not financial advice.
Sionna Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on medicines for cystic fibrosis. It develops galicaftor (SION-2222), a transmembrane domain 1 (TMD1)-directed CFTR that has completed Phase 2 trial; navocaftor (SION-3067), a potentiator that has completed Phase 2 trial; SION-109, an intracellular loop 4 directed CFTR corrector that has completed Phase 1 trial; SION-2851, a TMD1-directed CFTR corrector that has completed Phase 1 trial; SION-451, which is nucleotide-binding domain 1 stabilizer in Phase 1 trial; and SION-719, which is nucleotide-binding domain 1 stabilizer in Phase 2a proof-of-concept trial.
The company was formerly known as Sling Therapeutics, Inc. and changed its name to Sionna Therapeutics, Inc. in July 2021. Sionna Therapeutics, Inc. was incorporated in 2019 and is headquartered in Waltham, Massachusetts.
These items describe the scope and corporate basics of Sionna Therapeutics, including its focus on CF therapies.
Sionna Therapeutics, Inc. (SION) trades at $42.77 per share with a market cap of $1.93B and is ranked 2066. The stock sits in the healthcare sector with a current price near its forecasted trajectory.
The price outlook reflects a rising path across the forecast horizon, starting with a 2026 average of $42.77 and a 2026 max of $60.87, then advancing to a 2030 average of $71.49 and a 2050 average of $547.34 with a max of $1,135.73. The 2026 sentiment is NEUTRAL, turning BULLISH in subsequent years, supported by a series of higher annual averages and progressively larger max values.
In sum, the forecast projects meaningful upside from the current level, with substantial gains possible toward the end of the forecast window.
A major floor 34.7% below — a decisive break under it would weaken the trend.
The nearest floor, 26.0% below — buyers have tended to step in here.
Price is pressing into resistance (0.0% away) — a breakout level to watch.
A major ceiling 17.3% above — clearing it would confirm fresh momentum.
Key SION support and resistance from recent price action — levels where the trend has historically paused or reversed. Percentages are the distance from the current price.
A snapshot of SION market posture derived from its technical indicators and recent volatility. Higher trend and alignment lean bullish; higher risk means larger swings.
Technical Analysis
Indicators computed on daily closing prices.
| Period | SMA | Action | EMA | Action |
|---|---|---|---|---|
| MA 5 | $44.46 | Buy | $44.51 | Buy |
| MA 10 | $43.71 | Buy | $43.49 | Buy |
| MA 20 | $40.82 | Buy | $41.95 | Buy |
| MA 50 | $40.33 | Buy | $40.54 | Buy |
| MA 100 | $39.22 | Buy | $39.54 | Buy |
| MA 200 | $38.56 | Buy | $36.71 | Buy |
| Name | Value | Action |
|---|---|---|
| RSI (14) | 62.33 | Neutral |
| Stoch RSI (14) | 80.81 | Sell |
| CCI (20) | 95.88 | Neutral |
| Williams %R (14) | 0.00 | Info |
| MACD (12,26,9) | 0.53 | Buy |
| ROC (12) | 13.59 | Buy |
| Bollinger %B (20,2) | 0.82 | Neutral |
| Stochastic %K (14) | 100.00 | Sell |
| TRIX (15) | 0.39 | Buy |
| Awesome (5,34) | 4.47 | Buy |
| Ultimate (7,14,28) | 60.89 | Neutral |
| Momentum (10) | 2.52 | Buy |
| Aroon Osc (25) | 88.00 | Buy |
| Hull MA (9) | 45.20 | Buy |
| ADX (14) | 18.37 | Neutral |
| ATR (14) | 1.22 | Info |
The 30-day technical picture shows a bullish tilt in the broader trend, supported by price action around key moving averages. RSI is 60, while the price trades above the 50-day simple moving average of $39.93 and the 200-day simple moving average of $37.55.
Key near-term levels include a support at $33.51 and a resistance at $43.43. The 30-day range spans from $34.10 up to $53.65, indicating room for movement within a defined band before a sustained breakout occurs. Annualized volatility sits at 70%, reflecting higher-than-average price fluctuations.
| Year | Min | Avg | Max | ROI | Sentiment |
|---|---|---|---|---|---|
| $33.51 | $45.29 | $63.24 | 0% | Neutral | |
| $46.45 | $59.19 | $80.21 | +31% | Bullish | |
| $48.85 | $64.33 | $90.89 | +42% | Bullish | |
| $58.51 | $79.19 | $115.59 | +75% | Bullish | |
| $65.49 | $90.81 | $136.22 | +101% | Bullish | |
| $80.40 | $113.98 | $175.09 | +152% | Bullish | |
| $102.25 | $147.98 | $232.22 | +227% | Bullish | |
| $109.39 | $161.43 | $258.23 | +256% | Bullish | |
| $113.07 | $169.99 | $276.77 | +275% | Bullish | |
| $118.16 | $180.83 | $299.28 | +299% | Bullish | |
| $201.63 | $334.79 | $593.23 | +639% | Bullish | |
| $433.27 | $830.26 | $1,623.80 | +17.3x | Bullish |
Current year — the forecast is anchored to the live price, so ROI shows 0%.
| Month | Min | Avg | Max | Change |
|---|---|---|---|---|
| July 2026 | $33.51 | $45.29 | $54.40 | +0.00% |
| August 2026 | $39.48 | $46.77 | $57.03 | +3.27% |
| September 2026 | $41.27 | $49.30 | $60.90 | +5.41% |
| October 2026 | $41.55 | $49.98 | $62.40 | +1.38% |
| November 2026 | $40.56 | $49.09 | $61.85 | -1.78% |
| December 2026 | $40.91 | $49.79 | $63.24 | +1.42% |
Click any year to see its month-by-month SION forecast. Min / Avg / Max are a bear / base / bull scenario; ROI is the projected move from the current price. Change is the month-over-month move in the average. Estimates, not guarantees.
The SION price prediction for 2026 points to an average of $45.29 (low $33.51, high $63.24) — a potential gain of 0% on today's $45.29. Price action looks broadly range-bound.
In 2027, SION is projected to trade between $46.45 and $80.21, averaging $59.19 — a potential gain of +31% from today's $45.29. That is up +31% on the projected 2026 average. Buyers look set to stay in control over this stretch.
Sionna Therapeutics, Inc.'s 2028 outlook centres on $64.33, within a $48.85 to $90.89 range. That is up +9% on the projected 2027 average. That marks a +42% change versus current levels. Momentum favours further upside here.
By 2029, SION could reach as high as $115.59, with a base case around $79.19 and support toward $58.51 — roughly +75% from $45.29. Buyers look set to stay in control over this stretch.
Expect SION to range from $65.49 to $136.22 through 2030. The $90.81 average target implies a +101% move from current prices. That is up +15% on the projected 2029 average. Momentum favours further upside here.
The SION price prediction for 2031 points to an average of $113.98 (low $80.40, high $175.09) — a potential gain of +152% on today's $45.29. Buyers look set to stay in control over this stretch.
In 2032, SION is projected to trade between $102.25 and $232.22, averaging $147.98 — a potential gain of +227% from today's $45.29. That is up +30% on the projected 2031 average. Momentum favours further upside here.
Sionna Therapeutics, Inc.'s 2033 outlook centres on $161.43, within a $109.39 to $258.23 range. That is up +9% on the projected 2032 average. That marks a +256% change versus current levels. Buyers look set to stay in control over this stretch.
By 2034, SION could reach as high as $276.77, with a base case around $169.99 and support toward $113.07 — roughly +275% from $45.29. Momentum favours further upside here.
Expect SION to range from $118.16 to $299.28 through 2035. The $180.83 average target implies a +299% move from current prices. That is up +6% on the projected 2034 average. Buyers look set to stay in control over this stretch.
The SION price prediction for 2040 points to an average of $334.79 (low $201.63, high $593.23) — a potential gain of +639% on today's $45.29. Momentum favours further upside here.
In 2050, SION is projected to trade between $433.27 and $1,623.80, averaging $830.26 — a potential gain of +17.3x from today's $45.29. That is up +148% on the projected 2040 average. Buyers look set to stay in control over this stretch.
Investing $1,000 in SION today (≈ 22.079929 SION) could be worth
$18,332.17
+$17,332.17 (+1733%) by 2050 · US Dollar
Based on the average projected SION price of $830.26 in 2050.
Based on the base (average) forecast scenario. FX rates are indicative. Estimates only — not financial advice.
See what a past investment in SIONwould be worth at today's price.
$1,000 invested in SION on Jul 10, 2025 (≈ 47.755491 SION) would be worth
$2,162.85
+$1,162.85 (+116.3%) today · 2.16× · US Dollar
Based on a SION entry price of $20.94 vs. today's $45.29.
| Invested | Entry price | Value today | Return |
|---|---|---|---|
| 1 week ago | $43.99 | $1,029.55 | +3.0% |
| 1 month ago | $34.03 | $1,330.88 | +33.1% |
| 3 months ago | $37.89 | $1,195.3 | +19.5% |
| 6 months ago | $36.34 | $1,246.29 | +24.6% |
| 1 year ago | $20.94 | $2,162.85 | +116.3% |
| All time (1.4y) ago | $25 | $1,811.6 | +81.2% |
Past performance from historical market data — it does not predict future results. FX rates are indicative. Not financial advice.
Enter a price to see how it sits against our SION forecast.
Our base-case forecast reaches $91.00 around 2031.
Implied market cap at $91.00: $4.11B
The multi-year forecast shows a bullish trajectory across the horizon. By 2027 the average price is projected at $53.04 with a max of $73.60 and a 24% ROI; by 2028 the average is $55.55 and a max of $80.72 (ROI 29.9). By 2029 the average is $67.28 with a max of $101.36 (ROI 57.3), and by 2030 the average is $71.49 with a max of $111.01 (ROI 67.2).
Further out, 2031 shows an average of $88.98 and a max of $141.84 (ROI 108), 2032 an average of $119.09 with a max of $194.33 (ROI 178.4), 2033 an average of $122.01 with a max of $203.35 (ROI 185.3), 2034 an average of $125.00 with a max of $212.42 (ROI 192.3), and 2035 an average of $135.21 with a max of $233.92 (ROI 216.1).
The long-range view extends to 2040 with an average of $233.32 and a max of $434.94 (ROI 445.5), and to 2050 with an average of $547.34 and a max of $1,135.73 (ROI 1179.7). Across these years, sentiment remains BULLISH, with early-year neutrality in 2026 shifting to sustained upside thereafter. These are estimates, not guarantees, and actual results may vary.
Tap a question to reveal the answer.
The 2030 forecast shows an average price of $71.49, a min of $49.92, and a max of $111.01, with a 67.2% ROI and a BULLISH sentiment.
The forecast portrays a rising path from 2026 onward, with 2027 avg $53.04 (ROI 24), 2028 avg $55.55 (ROI 29.9), 2029 avg $67.28 (ROI 57.3), and 2030 avg $71.49 (ROI 67.2), culminating in a 2050 avg $547.34 (ROI 1179.7). The sentiment improves to BULLISH in later years.
Yes. The forecast shows a max above $100 by 2029 ($101.36) and above $100 again in 2030 ($111.01).
Bullish sentiment with RSI 60. The stock trades above the SMA50 of $39.93 and the SMA200 of $37.55, with support at $33.51 and resistance at $43.43. The 30-day range is $34.10 to $53.65, and annualized volatility is 70%.
Current price is $42.77 and market cap is $1.93B.
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