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Sionna Therapeutics, Inc. is projected to rise to $53.36 by 2027, a +23% move from its current price of $43.43. SION is currently trading above its 50-day average (a bullish sign). Technical indicators currently lean strong buy.
A data-driven summary — not financial advice. See the full breakdown below.
Live market data via Yahoo Finance · updated 5/28/2026
| Period | Min | Prediction | Max | Change |
|---|---|---|---|---|
| May 29 | $41.87 | $43.46 | $45.10 | +0.06% |
| May 30 | $41.26 | $43.49 | $45.83 | +0.13% |
| May 31 | $40.80 | $43.51 | $46.41 | +0.19% |
| Jun 1 | $40.42 | $43.54 | $46.90 | +0.26% |
| Jun 2 | $40.10 | $43.57 | $47.34 | +0.32% |
| Jun 3 | $39.81 | $43.60 | $47.75 | +0.39% |
| Jun 4 | $39.54 | $43.63 | $48.13 | +0.45% |
| Period | Min | Prediction | Max | Change |
|---|---|---|---|---|
| Week 1 | $39.54 | $43.63 | $48.13 | +0.45% |
| Week 2 | $38.14 | $43.82 | $50.36 | +0.91% |
| Week 3 | $37.13 | $44.02 | $52.19 | +1.37% |
| Week 4 | $36.33 | $44.22 | $53.83 | +1.82% |
| Week 5 | $35.66 | $44.42 | $55.34 | +2.29% |
| Week 6 | $35.08 | $44.62 | $56.77 | +2.75% |
| Week 7 | $34.56 | $44.83 | $58.14 | +3.22% |
Short-term targets derived from the forecast trend and recent volatility. Highly uncertain — not financial advice.
Sionna Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on the treatment of cystic fibrosis (CF). It researches and develops medicines for CF, including galicaftor (SION-2222), a transmembrane domain 1 (TMD1)-directed CFTR that has completed Phase 2 trial; navocaftor (SION-3067), a potentiator that has completed Phase 2 trial; SION-109, an intracellular loop 4 directed CFTR corrector that has completed Phase 1 trial; SION-2851, a TMD1-directed CFTR corrector that has completed Phase 1 trial; SION-451, a nucleotide-binding domain 1 stabilizer in Phase 1 trial; and SION-719, a nucleotide-binding domain 1 stabilizer in Phase 2a proof-of-concept trial.
The company was formerly known as Sling Therapeutics, Inc. and changed its name to Sionna Therapeutics, Inc. in July 2021. Sionna Therapeutics, Inc. was incorporated in 2019 and is headquartered in Waltham, Massachusetts.
Sionna Therapeutics, Inc. (SION) is a Healthcare company with a current price of $41.13 and a market capitalization of $1.86B. It is ranked 2053.
The near-term forecast shows a path for 2026 with a min of $33.92, an avg of $41.13, a max of $59.34, and an ROI of 0%. The forecast sentiment for 2026 is NEUTRAL.
Looking further out, the forecast envisions continued upside with a 2030 average of $64.94, a 2040 average of $224.72, and a 2050 average of $485.95, with a max of $1,091.52 and an overall long-run ROI of 1081.5%, reflecting a sustained bullish outlook across the horizon.
A major floor 22.3% below — a decisive break under it would weaken the trend.
The nearest floor, 13.8% below — buyers have tended to step in here.
The nearest ceiling, 5.8% above — a clean break opens room to run.
A major ceiling 16.9% above — clearing it would confirm fresh momentum.
Key SION support and resistance from recent price action — levels where the trend has historically paused or reversed. Percentages are the distance from the current price.
A snapshot of SION market posture derived from its technical indicators and recent volatility. Higher trend and alignment lean bullish; higher risk means larger swings.
Technical Analysis
Indicators computed on daily closing prices.
| Period | SMA | Action | EMA | Action |
|---|---|---|---|---|
| MA 5 | $41.74 | Buy | $42.08 | Buy |
| MA 10 | $41.17 | Buy | $41.62 | Buy |
| MA 20 | $41.31 | Buy | $41.31 | Buy |
| MA 50 | $39.98 | Buy | $40.40 | Buy |
| MA 100 | $39.25 | Buy | $39.05 | Buy |
| MA 200 | $36.08 | Buy | $35.60 | Buy |
| Name | Value | Action |
|---|---|---|
| RSI (14) | 56.11 | Neutral |
| Stoch RSI (14) | 59.99 | Neutral |
| CCI (20) | 74.62 | Neutral |
| Williams %R (14) | -30.47 | Info |
| MACD (12,26,9) | 0.06 | Buy |
| ROC (12) | -1.81 | Sell |
| Bollinger %B (20,2) | 0.74 | Neutral |
| Stochastic %K (14) | 69.53 | Neutral |
| TRIX (15) | 0.14 | Buy |
| Awesome (5,34) | 0.42 | Buy |
| Ultimate (7,14,28) | 59.40 | Neutral |
| Momentum (10) | 2.49 | Buy |
| Aroon Osc (25) | 32.00 | Buy |
| Hull MA (9) | 43.00 | Buy |
| ADX (14) | 10.29 | Neutral |
| ATR (14) | 1.48 | Info |
The 30-day technical picture is bullish. RSI(14) is 50, and the moving averages show SMA(50) at $39.74 and SMA(200) at $35.83. The 30-day price range runs from $31.91 to $53.02. Support sits at $37.43 and resistance at $45.95.
Annualized volatility is 70%, indicating substantial price fluctuations over a yearly horizon.
| Year | Min | Avg | Max | ROI | Sentiment |
|---|---|---|---|---|---|
| $33.92 | $43.43 | $62.78 | 0% | Neutral | |
| $40.23 | $53.36 | $76.05 | +23% | Bullish | |
| $42.17 | $58.42 | $87.54 | +35% | Bullish | |
| $46.38 | $66.67 | $103.90 | +54% | Bullish | |
| $47.22 | $70.17 | $113.00 | +62% | Bullish | |
| $61.54 | $94.31 | $156.26 | +117% | Bullish | |
| $77.61 | $122.43 | $208.09 | +182% | Bullish | |
| $73.97 | $119.95 | $208.60 | +176% | Bullish | |
| $76.32 | $127.09 | $225.71 | +193% | Bullish | |
| $80.18 | $137.00 | $248.07 | +215% | Bullish | |
| $126.85 | $244.49 | $479.86 | +463% | Bullish | |
| $242.70 | $539.33 | $1,187.55 | +11.4x | Bullish |
Current year — the forecast is anchored to the live price, so ROI shows 0%.
| Month | Min | Avg | Max | Change |
|---|---|---|---|---|
| May 2026 | $33.92 | $43.43 | $51.33 | +0.00% |
| June 2026 | $36.86 | $43.78 | $53.57 | +0.79% |
| July 2026 | $38.29 | $46.07 | $57.51 | +5.23% |
| August 2026 | $39.52 | $48.03 | $60.88 | +4.26% |
| September 2026 | $38.49 | $47.17 | $60.53 | -1.79% |
| October 2026 | $37.69 | $46.55 | $60.40 | -1.31% |
| November 2026 | $38.40 | $47.74 | $62.55 | +2.56% |
| December 2026 | $37.94 | $47.48 | $62.78 | -0.55% |
Click any year to see its month-by-month SION forecast. Min / Avg / Max are a bear / base / bull scenario; ROI is the projected move from the current price. Change is the month-over-month move in the average. Estimates, not guarantees.
The SION price prediction for 2026 points to an average of $43.43 (low $33.92, high $62.78) — a potential gain of 0% on today's $43.43. Price action looks broadly range-bound.
In 2027, SION is projected to trade between $40.23 and $76.05, averaging $53.36 — a potential gain of +23% from today's $43.43. That is up +23% on the projected 2026 average. Buyers look set to stay in control over this stretch.
Sionna Therapeutics, Inc.'s 2028 outlook centres on $58.42, within a $42.17 to $87.54 range. That is up +9% on the projected 2027 average. That marks a +35% change versus current levels. Momentum favours further upside here.
By 2029, SION could reach as high as $103.90, with a base case around $66.67 and support toward $46.38 — roughly +54% from $43.43. Buyers look set to stay in control over this stretch.
Expect SION to range from $47.22 to $113.00 through 2030. The $70.17 average target implies a +62% move from current prices. That is up +5% on the projected 2029 average. Momentum favours further upside here.
The SION price prediction for 2031 points to an average of $94.31 (low $61.54, high $156.26) — a potential gain of +117% on today's $43.43. Buyers look set to stay in control over this stretch.
In 2032, SION is projected to trade between $77.61 and $208.09, averaging $122.43 — a potential gain of +182% from today's $43.43. That is up +30% on the projected 2031 average. Momentum favours further upside here.
Sionna Therapeutics, Inc.'s 2033 outlook centres on $119.95, within a $73.97 to $208.60 range. That is -2% versus the projected 2032 average. That marks a +176% change versus current levels. Buyers look set to stay in control over this stretch.
By 2034, SION could reach as high as $225.71, with a base case around $127.09 and support toward $76.32 — roughly +193% from $43.43. Momentum favours further upside here.
Expect SION to range from $80.18 to $248.07 through 2035. The $137.00 average target implies a +215% move from current prices. That is up +8% on the projected 2034 average. Buyers look set to stay in control over this stretch.
The SION price prediction for 2040 points to an average of $244.49 (low $126.85, high $479.86) — a potential gain of +463% on today's $43.43. Momentum favours further upside here.
In 2050, SION is projected to trade between $242.70 and $1,187.55, averaging $539.33 — a potential gain of +11.4x from today's $43.43. That is up +121% on the projected 2040 average. Buyers look set to stay in control over this stretch.
Investing $1,000 in SION today (≈ 23.025558 SION) could be worth
$12,418.4
+$11,418.4 (+1142%) by 2050 · US Dollar
Based on the average projected SION price of $539.33 in 2050.
Based on the base (average) forecast scenario. FX rates are indicative. Estimates only — not financial advice.
See what a past investment in SIONwould be worth at today's price.
$1,000 invested in SION on May 27, 2025 (≈ 76.4526 SION) would be worth
$3,320.34
+$2,320.34 (+232.0%) today · 3.32× · US Dollar
Based on a SION entry price of $13.08 vs. today's $43.43.
| Invested | Entry price | Value today | Return |
|---|---|---|---|
| 1 week ago | $39.5 | $1,099.49 | +9.9% |
| 1 month ago | $39.21 | $1,107.63 | +10.8% |
| 3 months ago | $38 | $1,142.89 | +14.3% |
| 6 months ago | $43.57 | $996.79 | -0.3% |
| 1 year ago | $13.08 | $3,320.34 | +232.0% |
| All time (1.3y) ago | $25 | $1,737.2 | +73.7% |
Past performance from historical market data — it does not predict future results. FX rates are indicative. Not financial advice.
Enter a price to see how it sits against our SION forecast.
Our base-case forecast reaches $87.00 around 2031.
Implied market cap at $87.00: $3.93B
The multi-year forecast shows substantial upside over time. By 2030 the average price is $64.94 with a 57.9% ROI, and the 2050 average is $485.95 with an ROI of 1081.5%, illustrating a strong longer-term path if the projections unfold. The forecast also points to 2031 average of $88.12 (ROI 114.3%), 2032 average of $113.26 (ROI 175.4%), 2033 average of $110.72 (ROI 169.2%), 2034 average of $117.18 (ROI 184.9%), and 2035 average of $125.07 (ROI 204.1%), all within a bullish trajectory.
These figures are estimates and not guarantees, and they reflect a horizon where bullish sentiment persists for much of the forecast period.
Tap a question to reveal the answer.
The 2030 forecast shows an average price of $64.94, with a min of $43.14 and a max of $105.86, and an ROI of 57.9%. The sentiment for 2030 is BULLISH.
The long-run forecast shows bullish momentum, with an average price of $64.94 by 2030 and $485.95 by 2050, corresponding to ROIs of 57.9% and 1081.5%, respectively. These are estimates and not guarantees.
Yes. The 2030 forecast lists a max of $105.86, indicating a potential to reach above $100 in that year.
The 30-day range is from $31.91 to $53.02.
The current price is $41.13 and the market cap is $1.86B.
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