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Septerna, Inc. is projected to rise to $35.43 by 2027, a +19% move from its current price of $29.79. SEPN is currently trading above its 50-day average (a bullish sign). Technical indicators currently lean strong buy.
A data-driven summary — not financial advice. See the full breakdown below.
Live market data via Yahoo Finance · updated 5/28/2026
| Period | Min | Prediction | Max | Change |
|---|---|---|---|---|
| May 29 | $28.73 | $29.79 | $30.88 | -0.01% |
| May 30 | $28.31 | $29.78 | $31.34 | -0.02% |
| May 31 | $27.98 | $29.78 | $31.69 | -0.04% |
| Jun 1 | $27.71 | $29.78 | $32.00 | -0.05% |
| Jun 2 | $27.47 | $29.77 | $32.27 | -0.06% |
| Jun 3 | $27.26 | $29.77 | $32.51 | -0.07% |
| Jun 4 | $27.06 | $29.77 | $32.74 | -0.08% |
| Period | Min | Prediction | Max | Change |
|---|---|---|---|---|
| Week 1 | $27.06 | $29.77 | $32.74 | -0.08% |
| Week 2 | $26.00 | $29.74 | $34.03 | -0.17% |
| Week 3 | $25.20 | $29.72 | $35.04 | -0.25% |
| Week 4 | $24.54 | $29.69 | $35.92 | -0.33% |
| Week 5 | $23.98 | $29.67 | $36.70 | -0.41% |
| Week 6 | $23.48 | $29.64 | $37.43 | -0.50% |
| Week 7 | $23.02 | $29.62 | $38.10 | -0.58% |
Short-term targets derived from the forecast trend and recent volatility. Highly uncertain — not financial advice.
Septerna, Inc. is a clinical-stage biotechnology company that discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves' disease and thyroid eye disease.
In addition, it focuses on other therapeutic areas, including neurology, women's health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc.
and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.
Septerna, Inc. (SEPN) is currently trading at $30.65 with a market capitalization of $1.38B. It holds a rank of 2314 among listed assets. These numbers place the company in the Healthcare sector with a market position that reflects a small-to-mid cap biotechnology profile.
The forecasted path shows increasing average prices over time, with 2026 at $30.65 on average and higher levels projected for 2030, 2040 and 2050.
A major floor 30.3% below — a decisive break under it would weaken the trend.
The nearest floor, 21.3% below — buyers have tended to step in here.
Price is pressing into resistance (2.9% away) — a breakout level to watch.
A major ceiling 18.0% above — clearing it would confirm fresh momentum.
Key SEPN support and resistance from recent price action — levels where the trend has historically paused or reversed. Percentages are the distance from the current price.
A snapshot of SEPN market posture derived from its technical indicators and recent volatility. Higher trend and alignment lean bullish; higher risk means larger swings.
Technical Analysis
Indicators computed on daily closing prices.
| Period | SMA | Action | EMA | Action |
|---|---|---|---|---|
| MA 5 | $28.95 | Buy | $29.01 | Buy |
| MA 10 | $27.76 | Buy | $27.93 | Buy |
| MA 20 | $25.91 | Buy | $26.78 | Buy |
| MA 50 | $25.14 | Buy | $25.93 | Buy |
| MA 100 | $25.96 | Buy | $25.27 | Buy |
| MA 200 | $23.12 | Buy | $23.17 | Buy |
| Name | Value | Action |
|---|---|---|
| RSI (14) | 64.77 | Neutral |
| Stoch RSI (14) | 81.41 | Sell |
| CCI (20) | 132.00 | Buy |
| Williams %R (14) | -12.08 | Info |
| MACD (12,26,9) | 0.54 | Buy |
| ROC (12) | 24.80 | Buy |
| Bollinger %B (20,2) | 0.94 | Neutral |
| Stochastic %K (14) | 87.92 | Sell |
| TRIX (15) | 0.35 | Buy |
| Awesome (5,34) | 3.41 | Buy |
| Ultimate (7,14,28) | 70.36 | Sell |
| Momentum (10) | 4.95 | Buy |
| Aroon Osc (25) | 72.00 | Buy |
| Hull MA (9) | 30.09 | Sell |
| ADX (14) | 16.28 | Neutral |
| ATR (14) | 0.88 | Info |
The 30-day technical picture is bullish. RSI14 stands at 70, indicating strong momentum near overbought levels but still consistent with bullish sentiment. The chart shows a key moving-average support around $23.45 and a resistance at $30.65, with price activity contained within a 30-day range from $24.08 to $39.00.
| Year | Min | Avg | Max | ROI | Sentiment |
|---|---|---|---|---|---|
| $23.09 | $29.79 | $39.21 | 0% | Neutral | |
| $27.23 | $35.43 | $49.31 | +19% | Neutral | |
| $28.14 | $38.00 | $55.30 | +28% | Bullish | |
| $30.23 | $42.11 | $63.49 | +41% | Bullish | |
| $35.72 | $51.17 | $79.47 | +72% | Bullish | |
| $42.77 | $62.88 | $100.20 | +111% | Bullish | |
| $53.26 | $80.22 | $130.83 | +169% | Bullish | |
| $55.17 | $85.02 | $141.59 | +185% | Bullish | |
| $51.52 | $81.16 | $137.78 | +172% | Bullish | |
| $59.21 | $95.27 | $164.62 | +220% | Bullish | |
| $92.87 | $164.81 | $306.64 | +453% | Bullish | |
| $134.25 | $284.33 | $588.38 | +854% | Bullish |
Current year — the forecast is anchored to the live price, so ROI shows 0%.
| Month | Min | Avg | Max | Change |
|---|---|---|---|---|
| May 2026 | $23.09 | $29.79 | $35.24 | +0.00% |
| June 2026 | $25.26 | $29.87 | $36.32 | +0.27% |
| July 2026 | $24.64 | $29.47 | $36.46 | -1.34% |
| August 2026 | $25.13 | $30.32 | $38.02 | +2.88% |
| September 2026 | $25.13 | $30.54 | $38.71 | +0.71% |
| October 2026 | $23.92 | $29.27 | $37.46 | -4.15% |
| November 2026 | $23.58 | $29.02 | $37.47 | -0.85% |
| December 2026 | $24.35 | $30.13 | $39.21 | +3.82% |
Click any year to see its month-by-month SEPN forecast. Min / Avg / Max are a bear / base / bull scenario; ROI is the projected move from the current price. Change is the month-over-month move in the average. Estimates, not guarantees.
By 2026, SEPN could reach as high as $39.21, with a base case around $29.79 and support toward $23.09 — roughly 0% from $29.79. A consolidation phase looks the most probable path here.
Expect SEPN to range from $27.23 to $49.31 through 2027. The $35.43 average target implies a +19% move from current prices. That is up +19% on the projected 2026 average. Price action looks broadly range-bound.
The SEPN price prediction for 2028 points to an average of $38.00 (low $28.14, high $55.30) — a potential gain of +28% on today's $29.79. Buyers look set to stay in control over this stretch.
In 2029, SEPN is projected to trade between $30.23 and $63.49, averaging $42.11 — a potential gain of +41% from today's $29.79. That is up +11% on the projected 2028 average. Momentum favours further upside here.
Septerna, Inc.'s 2030 outlook centres on $51.17, within a $35.72 to $79.47 range. That is up +22% on the projected 2029 average. That marks a +72% change versus current levels. Buyers look set to stay in control over this stretch.
By 2031, SEPN could reach as high as $100.20, with a base case around $62.88 and support toward $42.77 — roughly +111% from $29.79. Momentum favours further upside here.
Expect SEPN to range from $53.26 to $130.83 through 2032. The $80.22 average target implies a +169% move from current prices. That is up +28% on the projected 2031 average. Buyers look set to stay in control over this stretch.
The SEPN price prediction for 2033 points to an average of $85.02 (low $55.17, high $141.59) — a potential gain of +185% on today's $29.79. Momentum favours further upside here.
In 2034, SEPN is projected to trade between $51.52 and $137.78, averaging $81.16 — a potential gain of +172% from today's $29.79. That is -5% versus the projected 2033 average. Buyers look set to stay in control over this stretch.
Septerna, Inc.'s 2035 outlook centres on $95.27, within a $59.21 to $164.62 range. That is up +17% on the projected 2034 average. That marks a +220% change versus current levels. Momentum favours further upside here.
By 2040, SEPN could reach as high as $306.64, with a base case around $164.81 and support toward $92.87 — roughly +453% from $29.79. Buyers look set to stay in control over this stretch.
Expect SEPN to range from $134.25 to $588.38 through 2050. The $284.33 average target implies a +854% move from current prices. That is up +73% on the projected 2040 average. Momentum favours further upside here.
Investing $1,000 in SEPN today (≈ 33.568312 SEPN) could be worth
$9,544.54
+$8,544.54 (+854%) by 2050 · US Dollar
Based on the average projected SEPN price of $284.33 in 2050.
Based on the base (average) forecast scenario. FX rates are indicative. Estimates only — not financial advice.
See what a past investment in SEPNwould be worth at today's price.
$1,000 invested in SEPN on May 27, 2025 (≈ 103.626947 SEPN) would be worth
$3,087.05
+$2,087.05 (+208.7%) today · 3.09× · US Dollar
Based on a SEPN entry price of $9.65 vs. today's $29.79.
| Invested | Entry price | Value today | Return |
|---|---|---|---|
| 1 week ago | $28.01 | $1,063.55 | +6.4% |
| 1 month ago | $25.09 | $1,187.33 | +18.7% |
| 3 months ago | $30.28 | $983.82 | -1.6% |
| 6 months ago | $29.02 | $1,026.53 | +2.7% |
| 1 year ago | $9.65 | $3,087.05 | +208.7% |
| All time (1.6y) ago | $21.4 | $1,392.06 | +39.2% |
Past performance from historical market data — it does not predict future results. FX rates are indicative. Not financial advice.
Enter a price to see how it sits against our SEPN forecast.
Our base-case forecast reaches $60.00 around 2031.
Implied market cap at $60.00: $2.7B
The multi-year forecast outlines a bullish trajectory across the coming years. For 2026, the min is $23.09, the avg is $30.65, the max is $40.65, ROI 0, and sentiment is Neutral. By 2030, the avg is $55.29 with a max of $86.23, min $38.44, ROI 80.4%, and sentiment Bullish.
In 2040, the avg rises to $186.04 with a min of $103.90, a max of $348.26, ROI 507.1%, and sentiment Bullish. By 2050, the avg is $326.71, with a min of $152.13, a max of $680.93, ROI 966.1%, and sentiment Bullish. These are estimates and not guarantees, and actual results may vary over time.
Tap a question to reveal the answer.
2030 avg $55.29; min $38.44; max $86.23; ROI 80.4%; sentiment BULLISH. These figures are estimates and not guaranteed.
Forecasts show a path of rising averages from 2026 onward (2026 avg $30.65; 2027 avg $36.98; 2028 avg $40.09; 2029 avg $44.85; 2030 avg $55.29) with improving ROI to 80.4% by 2030 and a Bullish sentiment through later years. These are estimates and not guarantees.
The max forecast for 2030 is $86.23, indicating that reaching beyond $70 is within the projected upper range for that year. These figures are estimates and not guaranteed.
2026 min $23.09, avg $30.65, max $40.65; ROI 0%; sentiment Neutral. These are estimates and not guaranteed.
2040 avg $186.04; min $103.90; max $348.26; ROI 507.1%; sentiment BULLISH. These are estimates and not guaranteed.
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